Studies

What is this study?

Alzheimer’s disease (AD) is characterised by worsening of memory and cognitive impairment. Accumulating evidence suggests that neurodegeneration in AD is associated with astrocyte upregulation, one of the prime markers of neuroinflammation. The aim of this research study is to evaluate brain changes seen in some Alzheimer’s disease patients using a novel astroglial activation imaging marker [11C]BU99008. You will be helping to gather information about the changes that occur in the brain in people with Alzheimer’s disease; this could help us to develop effective preventative treatments in the future.

Who are we looking for?

We are interested in recruiting people with no memory problems (healthy controls) and people with Alzheimer’s disease aged 50 years and older. Refreshments will be provided and you could be paid up to £290 for your time.

What the study involves

There are normally 2 to 3 appointments. The first visit will involve a medical screening and blood test (taking about an hour) and a cognitive assessment (taking about 2 hours). Then you will have an fMRI scan and PET scan (one and a half hours). You will then come back for two additional PET scans.

All visits take place at Hammersmith Hospital

What to do if I am interested

For more information about this study, please contact:
The Memory Team Email: memory@imperial.ac.uk
Telephone: 0208 383 3704 or 0208 383 1969 or 0208 383 4850.