A phase II trial evaluating the treatment of the diabetic medication, Liraglutide, as a potential new treatment for patients with mild to moderate Alzheimer’s disease.Read More
Dr Edison is a Clinical Senior Lecturer in the Division of Brain Sciences at Imperial College London and a visiting Professor at Cardiff University, Wales. He is also a Consultant Physician at Hammersmith Hospital, London.
Dr Edison’s research has focused on neuroimaging with novel molecular probes using PET and magnetic resonance techniques for imaging pathophysiological changes associated with Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. He has extensive experience in PET imaging in different neurodegenerative and neuroinflammatory conditions. Combined with his clinical expertise in different types of degenerative diseases and dementia, he has investigated the relationship between amyloid deposition, microglial activation, and glucose metabolism in various disorders, along with evaluating different transporters in the brain. His work in assessing microglial activation and amyloid load showed that both of these are increased in Alzheimer’s disease, and that microglial activation correlates with cognition, while amyloid load does not correlate with cognition. He was an MRC Clinical Research Fellow before he became a HEFCE Clinical Senior Lecturer.
His work now focuses on neuroinflammation and the interplay between inflammation and immunity in neurodegenerative and neuroinflammatory disease, and relating these with genetic information. He is also evaluating methods of modulating inflammation and amyloid in Alzheimer’s disease, and the influence of cardiometabolic factors on the development of neurodegenerative diseases by means of clinical and preclinical studies.
Our Current Studies
Neuro inflammation and Amyloid Study
Investigating the relationship between inflammation and amyloid in the brains of patients with mild cognitive impairment and Alzheimer’s disease.Read More
Microglial Activation in Alzheimer’s Disease and Mild Cognitive Impairment
Investigating the relationship between inflammation and amyloid in the brains of patients with mild cognitive impairment and Alzheimer’s disease using a novel tracer.Read More
Astroglial Activation, β-amyloid Deposition and Neuronal Activity in AD
Investigating the relationship between astroglia and amyloid in the brains of people with Alzheimer’s disease and mild cognitive impairment, and how this affects thinking and memory using a novel astroglial activation imaging marker.Read More
Surgery and Neuroinflammation
A study looking at the relationship between inflammation in the brain and obesity in patient’s undergoing gastric bypass surgery. This study involves a PET and MRI scan prior to the surgery, and then again 6 months after the surgery.Read More
Uptake and Kinetics of [18F]ICMT11
Evaluating brain changes seen in some Alzheimer’s disease patients (protein build-up and specific proteins activity in the brain).Read More