Antidiabetic drugs in Alzheimer’s disease - mechanisms of action and future perspectives
Summary
Diabetes and Alzheimer's disease are both very common conditions in the UK’s elderly. In the last 20 years, a link has been suggested between these diseases. Insulin resistance in the central nervous system (brain, spinal cord and cerebrospinal fluid) may play a common role in both diseases. There have been preclinical studies that suggest that some antidiabetic drugs may have protective properties effects in the brain.
This article discusses the different mechanism of antidiabetic medications and their potential use in treating Alzheimer’s disease.
| Title | Antidiabetic Drugs in Alzheimer’s Disease: Mechanisms of Action and Future Perspectives |
|---|---|
| Authors | Grazia Daniela Femminella; Leonardo Bencivenga; Laura Petraglia; Lucia Visaggi; Lucia Gioia; Fabrizio Vincenzo Grieco; Claudio de Lucia; Klara Komici; Graziamaria Corbi; Paul Edison; Giuseppe Rengo; Nicola Ferrara |
| Journal | Journal of Diabetes Research, 2017:7420796 |
| Published | 1 June 2017 |
| DOI | 10.1155/2017/7420796 |
| Full Article | Publisher page / PubMed / PMC full text |